Effects of short-term hyperoxic ventilation on lung, kidney, heart, and liver in a rat model: A biochemical evaluation Kısa süreli hiperoksik ventilasyonun bir sıçan modelinde akciğer, böbrek, kalp ve karaciğer üzerine etkileri: Biyokimyasal değerlendirme

AKSU U., ULUGOL H., Orhan Sungur M., Şentürk E., VARDAR K., Şentürk M., ...Daha Fazla

Ulusal Travma ve Acil Cerrahi Dergisi, cilt.27, sa.5, ss.497-503, 2021 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.14744/tjtes.2020.85529
  • Dergi Adı: Ulusal Travma ve Acil Cerrahi Dergisi
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.497-503
  • Anahtar Kelimeler: Hyperoxia, Hyperoxic ventilation, Mechanical ventilation, Organ injury
  • İstanbul Kent Üniversitesi Adresli: Evet

Özet

BACKGROUND: Despite studies on the adverse effects of hyperoxia, its use is still recommended by the World Health Organiza-tion. The aim of this study was to test the possible harmful effects of hyperoxia on the lung, kidney, heart, and liver in a rat mechanical ventilation model. METHODS: Male Wistar rats were randomly assigned into two groups (n=6/group): Normoxic (FiO2: 0.3) or hyperoxic (FiO2: 1.0) ventilation for 4 h. The injury was evaluated in bronchoalveolar lavage (BAL), blood, lung, liver, kidney, and heart was evaluated in terms of cell surface integrity, extracellular matrix (sialic acid, syndecan-1), osmotic stress (free hemoglobin), and redox homeostasis-lipid peroxidaation (malondialdehyde). BAL and wet/dry weight ratio were also evaluated for cellular permeability. RESULTS: Four hours of hyperoxic ventilation did not lead to significant changes in (1) sialic acid, syndecan-1, (2) malondialdehyde levels and wet/dry weight ratio in liver, kidney, heart, and lung compared to normoxic ventilation. CONCLUSION: Mechanical ventilation with hyperoxia seems to have almost similar effects compared to ventilation with normoxia. However, the long term effect of hyperoxia should be evaluated.