Old disease—New reflections: Gaucher, immunity, and inflammation


Şoroğlu C. V., BERKAY E. G.

Journal of Cellular and Molecular Medicine, cilt.28, sa.20, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 28 Sayı: 20
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1111/jcmm.70087
  • Dergi Adı: Journal of Cellular and Molecular Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, MEDLINE, Directory of Open Access Journals
  • Anahtar Kelimeler: COVID-19, Gaucher disease, Glucocerebrosidase, immunity, neuroinflammation
  • İstanbul Kent Üniversitesi Adresli: Evet

Özet

Gaucher disease (GD) is the most common lysosomal storage disease. It is a multisystemic metabolic disease caused by GBA pathogenic mutations. Although the general symptoms have been known for a long time, new treatment possibilities, the detection of different biomarkers, and innovations in diagnosis and follow-up have paved the way for further studies. Recent studies have shown that the immune system has become an essential factor associated with disease progression. The role of Gaucher cells in the disease is well characterized. In addition to phagocytic macrophage cells, lymphocytes, complement system, and inflammatory pathway elements are also implicated in GD as they were shown to be the underlying factors causing associated pathologies such as Parkinson's. In this article, the relationship between the GD and the immune system has been examined and reviewed in light of new findings.