Akademik Veri Yönetim Sistemi
Nobel Medicus, cilt.13, sa.1, ss.26-30, 2017 (Scopus)
Objective: The purpose of this investigation was to evaluate the effect of valproic acid therapy on dental and periodontal health of children with epilepsy and to compare salivary lysozyme concentrations of epileptic patients with an otherwise healthy group of children. Material and Method: The study group included 27 patients with epilepsy and the control group consisted of 12 healthy children. Study group was divided into two sub-groups as; (VPA): 12 patients who were using only valproic acid and, (VPA+AED): 15 patients who were using valproic acid in combination with different antiepileptic drugs (AED). For the assessment of salivary lysozyme concentration, unstimulated mixed saliva was collected from each patient with expectoration method. Buffering capacity and flow rate of saliva were established using standard methods and the salivary concentration of lysozyme was evaluated using turbidimetric method. Intraoral examinations of all subjects were done according to WHO criteria. Results: Salivary lysozyme levels were significantly higher in the study group as well as the plaque and gingival indices. There was no statistically significant difference between the groups in terms of dental experience scores, salivary buffering capacity and salivary flow rates. A positive correlation was observed between the clinical periodontal health and salivary lysozyme concentrations in epileptic patients. Conclusion: Elevation of salivary lysozyme concentrations may directly affect periodontal and oral health of epileptic patients. We need more studies to develop new AEDs which are compatible with oral tissues.