Calcium channel blockers prevent stress-induced ulcers in rats

YEGEN B., Alican I., Süha Yalçin A. S., Oktay S.

Agents and Actions, cilt.35, sa.1-2, ss.130-134, 1992 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 1-2
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1007/bf01990962
  • Dergi Adı: Agents and Actions
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.130-134
  • İstanbul Kent Üniversitesi Adresli: Hayır

Özet

Gastric mucosal damaged induced by cold and restraint stress caused increase in gastric lipid peroxidation (LP) and decrease in gastric glutathione levels. Two calcium-channel blockers, verapamil and nicardipine, prevented stress-induced increase in gastric LP, as well as ulcer formation. Both calcium-channel blockers protected against stress-induced ulcers, and inhibition of LP may be among their mechanisms of action. © 1992 Birkhäuser Verlag.