Calcium channel blockers prevent stress-induced ulcers in rats
Agents and Actions, cilt.35, sa.1-2, ss.130-134, 1992 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 1-2
- Basım Tarihi: 1992
- Doi Numarası: 10.1007/bf01990962
- Dergi Adı: Agents and Actions
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.130-134
- İstanbul Kent Üniversitesi Adresli: Hayır
Özet
Gastric mucosal damaged induced by cold and restraint stress caused increase in gastric lipid peroxidation (LP) and decrease in gastric glutathione levels. Two calcium-channel blockers, verapamil and nicardipine, prevented stress-induced increase in gastric LP, as well as ulcer formation. Both calcium-channel blockers protected against stress-induced ulcers, and inhibition of LP may be among their mechanisms of action. © 1992 Birkhäuser Verlag.