Curcumins-Loaded ZIF-8 Nanoparticles-Embedded Transdermal Polymeric Patches Increase Apoptosis and Reduce Necrosis in a Dose-Dependent Manner in MCF-7 Cells

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Kiyak Kirmaci H., Aydin S., Yekeler H. B., Güler E., Kayaci A. B., Gürer Z., ...Daha Fazla

NANO SELECT, ss.70048, 2025 (ESCI)

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1002/nano.70048
  • Dergi Adı: NANO SELECT
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.70048
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • İstanbul Kent Üniversitesi Adresli: Evet

Özet

Curcumin(Cur)‐loaded zeolitic imidazolate framework‐8 (ZIF‐8) nanoparticles (Cur@ZIF‐8 NPs) were produced to increase the anticancer activity of Cur. Cur@ZIF‐8 NPs were embedded in polycaprolactone (PCL) fibers as transdermal polymeric patches via a pressured gyration (PG) method to provide controlled release. Cur@ZIF‐8 NPs and Cur@ZIF‐8 NPs‐embedded PCL fibers were characterized for physical, chemical, mechanical, and thermal properties, also biological activities were examined with in vitro tests. Cur@ZIF‐8 NPs were produced homogeneously with a size of ∼200 nm and a zeta potential of ∼−19 mV. Cur had better stability inside Cur@ZIF‐8 NPs than its powder form. Cur@ZIF‐8 NPs were successfully loaded in PCL fibers with a size of ∼7 µm, and Cur@ZIF‐8 NPs were dispersed amorphously in fibers. Cur was released in a controlled manner, and its efficiency was increased in the acidic …