The effect of chronic ethanol ingestion on hepatic lipid peroxide, glutathione, glutathione peroxidase and glutathione transferase in rats

Aykaç G., Uysal M., Süha Yalçin A. S., Koçak-Toker N., Sivas A., Öz H.

Toxicology, cilt.36, sa.1, ss.71-76, 1985 (Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 1
  • Basım Tarihi: 1985
  • Doi Numarası: 10.1016/0300-483x(85)90008-3
  • Dergi Adı: Toxicology
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.71-76
  • Anahtar Kelimeler: Chronic ethanol, Glutathione peroxidase, Glutathione transferase, Lipid peroxidation, Liver
  • İstanbul Kent Üniversitesi Adresli: Hayır

Özet

Water containing 20% ethanol was given for a period of 3, 6 and 9 weeks to rats, and changes in hepatic lipid peroxide, glutathione, glutathione peroxidase and glutathione transfereses were investigated. Lipid peroxide levels and glutathione peroxidase activities remained unchanged after 3 weeks and started to increase thereafter. Glutathione levels and glutathione transferase activities were significantly increased following ethanol consumption. These results show that chronic ethanol consumption stimulates hepatic lipid peroxidation in rats. This stimulation is not dependent on glutathione depletion and the increased glutathione peroxidase and glutathione transferase activities may reflect an adaptive change against ethanol-induced lipid peroxide toxicity. © 1985.