Imaging Reactive Oxygen Species-Induced Modifications in Living Systems
Antioxidants and Redox Signaling, vol.24, no.16, pp.939-958, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 24 Issue: 16
- Publication Date: 2016
- Doi Number: 10.1089/ars.2015.6415
- Journal Name: Antioxidants and Redox Signaling
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.939-958
- Istanbul Kent University Affiliated: No
Abstract
Significance: Reactive Oxygen Species (ROS) may regulate signaling, ion channels, transcription factors, and biosynthetic processes. ROS-related diseases can be due to either a shortage or an excess of ROS. Recent Advances: Since the biological activity of ROS depends on not only concentration but also spatiotemporal distribution, real-time imaging of ROS, possibly in vivo, has become a need for scientists, with potential for clinical translation. New imaging techniques as well as new contrast agents in clinically established modalities were developed in the previous decade. Critical Issues: An ideal imaging technique should determine ROS changes with high spatio-temporal resolution, detect physiologically relevant variations in ROS concentration, and provide specificity toward different redox couples. Furthermore, for in vivo applications, bioavailability of sensors, tissue penetration, and a high signal-to-noise ratio are additional requirements to be satisfied. Future Directions: None of the presented techniques fulfill all requirements for clinical translation. The obvious way forward is to incorporate anatomical and functional imaging into a common hybrid-imaging platform.