Calcium channel blockers prevent stress-induced ulcers in rats
Agents and Actions, vol.35, no.1-2, pp.130-134, 1992 (Scopus)
- Publication Type: Article / Article
- Volume: 35 Issue: 1-2
- Publication Date: 1992
- Doi Number: 10.1007/bf01990962
- Journal Name: Agents and Actions
- Journal Indexes: Scopus
- Page Numbers: pp.130-134
- Istanbul Kent University Affiliated: No
Abstract
Gastric mucosal damaged induced by cold and restraint stress caused increase in gastric lipid peroxidation (LP) and decrease in gastric glutathione levels. Two calcium-channel blockers, verapamil and nicardipine, prevented stress-induced increase in gastric LP, as well as ulcer formation. Both calcium-channel blockers protected against stress-induced ulcers, and inhibition of LP may be among their mechanisms of action. © 1992 Birkhäuser Verlag.