Prof. Atilla AKDEMİR

Publication Network

Articles 74

1. Novel triazole-urea hybrids as promising EGFR inhibitors: Synthesis, molecular modeling and antiproliferative activity studies against breast cancer

TÜRE A., Gülcan M. M., DİNGİŞ BİRGÜL S. İ., Erdoğan O., Erdoğan Ö., ÖZ TUNCAY F., et al.

Journal of Molecular Structure , vol.1347, 2025 (SCI-Expanded, Scopus) Sustainable Development

2. Synthesis, in-vitro, in-silico, and global DNA methylation studies of curcumin-benzoquinone analog in triple-negative breast cancer (TNBC) cells

Günçer B., ÖZKÖK F., Aldoǧan E. H., Oyaci Y., Nazligül E., ÖZERMAN EDİS B., et al.

Toxicology Research , vol.14, no.4, 2025 (SCI-Expanded, Scopus)

3. Novel sulfonamide-based compounds as dual inhibitors of hCYP1B1 and hCYP19A1 with anticancer activity against breast cancer cells

İnce-Ergüç E., Eraslan-Elma P., Akdemir A., KARALI N. L., GÜRER ORHAN H.

Journal of Research in Pharmacy , vol.29, no.3, pp.1098-1110, 2025 (ESCI, Scopus, TRDizin)

4. Synthesis, In Vitro Evaluation, and Molecular Docking Studies of Novel 3,5-Diphenyl-1H-1,2,4-Triazole Derivatives as Potential hEGFR Inhibitors

KOLCUOĞLU Y., BEKİRCAN O., Ustalar N., TÜRE A., Akdemir A., Sanlier S. H.

Archiv der Pharmazie , vol.358, no.5, 2025 (SCI-Expanded, Scopus)

5. The Quest for Ligands Against Kinesin Motor Protein Eg5

Sahin A. F., Carradori S., Ricci A., Rashad M., Akdemir A.

Archiv der Pharmazie , vol.358, no.5, 2025 (SCI-Expanded, Scopus)

6. In silico design, synthesis and antitubercular activity of novel 2-acylhydrazono-5-arylmethylene-4-thiazolidinones as enoyl-acyl carrier protein reductase inhibitors

DİNGİŞ BİRGÜL S. İ., Kumari J., Tamhaev R., Mourey L., Lherbet C., Sriram D., et al.

Journal of Biomolecular Structure and Dynamics , vol.43, no.13, pp.6681-6699, 2025 (SCI-Expanded, Scopus)

7. Urease inhibitors for the treatment of H. pylori

GÜZEL AKDEMİR Ö., Akdemir A.

Expert Opinion on Therapeutic Patents , vol.35, no.1, pp.17-30, 2025 (SCI-Expanded, Scopus)

8. Discovery and evaluation of novel pyrrole/thiophene chalcone urea EGFR inhibitors via biological and docking studies

ZENGİN KURT B., ÖZTÜRK CİVELEK D., ŞAHİN BEKTAY H., Özbilge Ulueren A., KOLCUOĞLU Y., Akdemir A., et al.

Future Medicinal Chemistry , vol.17, no.12, pp.1423-1438, 2025 (SCI-Expanded, Scopus)

9. Design, Synthesis, and Investigation of Anticancer and Antioxidant Potential of Novel Indole-Based Melatonin Analogues in Breast Cancer

Ince-Erguc E., Durgun K., AKDEMİR A., SÜZEN S., GÜRER ORHAN H.

CHEMISTRYSELECT , vol.9, no.25, 2024 (SCI-Expanded, Scopus)

10. Novel 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide based thiosemicarbazides as potent and selective inhibitors of tumor-associated human carbonic anhydrase IX and XII: Synthesis, cytotoxicity, and molecular modelling studies

DEMİR YAZICI K., TRAWALLY M., Bua S., ÖZTÜRK CİVELEK D., Akdemir A., Supuran C. T., et al.

Bioorganic Chemistry , vol.144, 2024 (SCI-Expanded, Scopus)

11. Synthesis of naproxen thiadiazole urea hybrids and determination of their anti-melanoma, anti-migration, tyrosinase inhibitory activity, and molecular docking studies

ZENGİN KURT B., Altundağ Ö., GÖKÇE M., Cakmak U., Tuncay F. O., KOLCUOĞLU Y., et al.

Journal of Molecular Structure , vol.1295, 2024 (SCI-Expanded, Scopus)

12. Antiviral Properties of 5-Sulfamoyl-1H-Indole-Linked Spirothiazolidinone Derivatives: A Study on Human Parainfluenza Virus-2

TRAWALLY M., OLCAY F. N., ÖZBEK ÇELİK B., Akdemir A., GÜZEL AKDEMİR Ö.

Journal of Research in Pharmacy , vol.28, no.1, pp.213-224, 2024 (ESCI, Scopus, TRDizin)

13. Thiosemicarbazone-benzenesulfonamide Derivatives as Human Carbonic Anhydrases Inhibitors: Synthesis, Characterization, and In silico Studies

TRAWALLY M., DEMİR YAZICI K., Angeli A., Kaya K., Akdemir A., Supuran C. T., et al.

Anti-Cancer Agents in Medicinal Chemistry , vol.24, no.9, pp.649-667, 2024 (SCI-Expanded, Scopus)

14. Synthesis of flurbiprofen thiadiazole urea derivatives and assessment of biological activities and molecular docking studies

ZENGİN KURT B., Altundağ Ö., Tokgöz M. N., ÖZTÜRK CİVELEK D., Tuncay F. O., Cakmak U., et al.

Chemical Biology and Drug Design , vol.102, no.6, pp.1458-1468, 2023 (SCI-Expanded, Scopus)

15. Dithiocarbamates and dithiocarbonates containing 6-nitrosaccharin scaffold: Synthesis, antimycobacterial activity and in silico target prediction using ensemble docking-based reverse virtual screening

TRAWALLY M., DEMİR YAZICI K., İpek Dingiş-Birgül S., Kaya K., Akdemir A., GÜZEL AKDEMİR Ö.

Journal of Molecular Structure , vol.1277, 2023 (SCI-Expanded, Scopus)

16. Tail-Approach-Based Design and Synthesis of Coumarin-Monoterpenes as Carbonic Anhydrase Inhibitors and Anticancer Agents

ZENGİN KURT B., ÇELEBİ G., ÖZTÜRK CİVELEK D., Angeli A., Akdemir A., Sonmez F., et al.

ACS Omega , vol.8, no.6, pp.5787-5807, 2023 (SCI-Expanded, Scopus)

17. Design and synthesis of new heterocyclic compounds containing 5-[(1H-1,2,4-triazol-1-yl)methyl]-3H-1,2,4-triazole-3-thione structure as potent hEGFR inhibitors

KOLCUOĞLU Y., BEKİRCAN O., Fazli H., Sahin E., TÜRE A., AKDEMİR A., et al.

Journal of Biomolecular Structure and Dynamics , vol.41, no.22, pp.12753-12767, 2023 (SCI-Expanded, Scopus) Sustainable Development

18. Anti-SARS-CoV-2 and cytotoxic activity of two marine alkaloids from green alga Caulerpa cylindracea Sonder in the Dardanelles

Erol E., Orhan M. D., Avsar T., Akdemir A., Okudan E. S., Alim Toraman G. Ö., et al.

RSC ADVANCES , vol.12, no.46, pp.29983-29990, 2022 (SCI-Expanded, Scopus)

19. Azole-Based Compounds That Are Active against Candida Biofilm: In Vitro, In Vivo and In Silico Studies

Carradori S., Ammazzalorso A., De Filippis B., Sahin A. F., AKDEMİR A., Orekhova A., et al.

ANTIBIOTICS-BASEL , vol.11, no.10, 2022 (SCI-Expanded, Scopus)

20. New Pyridinium Salt Derivatives of 2-(Hydrazinocarbonyl)-3-phenyl-1H-indole-5- sulfonamide as Selective Inhibitors of Tumour-Related Human Carbonic Anhydrase Isoforms IX and XII

Güzel Akdemir Ö., Demir Yazıcı K., Akdemir A.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY , vol.22, no.14, pp.2637-2646, 2022 (SCI-Expanded, Scopus)

21. New 1H-indole-2,3-dione 3-thiosemicarbazones with 3-sulfamoylphenyl moiety as selective carbonic anhydrase inhibitors

Eraslan-Elma P., AKDEMİR A., Berrino E., Bozdag M., Supuran C. T., Karali N.

ARCHIV DER PHARMAZIE , vol.355, no.8, 2022 (SCI-Expanded, Scopus)

22. Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII

GÜMÜŞ PALABIYIK A., Bozdag M., AKDEMİR A., Angeli A., Selleri S., Carta F., et al.

MOLECULES , vol.27, no.14, 2022 (SCI-Expanded, Scopus)

23. Synthesis, anti-TB activities, and molecular docking studies of 4-(1,2,3-triazoyl)arylmethanone derivatives.

Turkmen Y., Yagiz Erdemir G., Yuksel Mayda P., Akdemir A., Gunaydin Akyildiz A., Altundas A.

Journal of biochemical and molecular toxicology , vol.36, 2022 (SCI-Expanded, Scopus)

24. Mandelic acid-based spirothiazolidinones targeting M. tuberculosis: Synthesis, in vitro and in silico investigations

Trawally M., DEMİR YAZICI K., DİNGİŞ BİRGÜL S. İ., Kaya K., AKDEMİR A., GÜZEL AKDEMİR Ö.

Bioorganic Chemistry , vol.121, 2022 (SCI-Expanded, Scopus) Sustainable Development

25. The neutralization effect of montelukaston SARS-CoV-2 is shown by multiscale in silicosimulations and combined in vitro studies.

Durdagi S., Avsar T., Orhan M. D., Serhatli M., Balcioglu B. K., Ozturk H. U., et al.

Molecular therapy : the journal of the American Society of Gene Therapy , vol.30, pp.963-974, 2022 (SCI-Expanded, Scopus)

26. In vitro evaluation of estrogenic, antiestrogenic and antitumor effects of amentoflavone.

Aliyev A. T., Ozcan-Sezer S., Akdemir A., Gurer-Orhan H.

Human & experimental toxicology , vol.40, pp.1510-1518, 2021 (SCI-Expanded, Scopus) Sustainable Development

27. Synthesis of new 1,2,4-triazole-(thio)semicarbazide hybrid molecules: Their tyrosinase inhibitor activities and molecular docking analysis

Gultekin E., BEKİRCAN O., KOLCUOĞLU Y., AKDEMİR A.

ARCHIV DER PHARMAZIE , vol.354, 2021 (SCI-Expanded, Scopus) Sustainable Development

28. Quinoline-sulfamoyl carbamates/sulfamide derivatives: Synthesis, cytotoxicity, carbonic anhydrase activity, and molecular modelling studies

Cakmak E. B., ZENGİN KURT B., ÖZTÜRK CİVELEK D., Angeli A., Akdemir A., Sonmez F., et al.

Bioorganic Chemistry , vol.110, 2021 (SCI-Expanded, Scopus)

29. New azolyl-derivatives as multitargeting agents against breast cancer and fungal infections: synthesis, biological evaluation and docking study

Maccallini C., Gallorini M., Sisto F., AKDEMİR A., Ammazzalorso A., De Filippis B., et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY , vol.36, no.1, pp.1632-1645, 2021 (SCI-Expanded, Scopus) Sustainable Development

30. Molecular modelling studies to suggest novel scaffolds against SARS-CoV-2 target enzymes

Şahin A. F., Küçükgüzel Ş. G., Akdemir A.

Journal of Research in Pharmacy , vol.25, no.6, pp.1010-1017, 2021 (ESCI, Scopus, TRDizin) Sustainable Development

31. Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

Angeli A., Carta F., Nocentini A., Winum J., Zalubovskis R., AKDEMİR A., et al.

METABOLITES , vol.10, no.10, 2020 (SCI-Expanded, Scopus)

32. Design and synthesis of novel peptidomimetics for cancer immunotherapy

Kose C., Uysal E., Yazici B., Tugay Z., Dingis-Birgul S. İ., Yanik H., et al.

ORGANIC COMMUNICATIONS , vol.13, no.3, pp.89-102, 2020 (ESCI, Scopus, TRDizin)

33. Novel Indole-Based Hydrazones as Potent Inhibitors of the α-class Carbonic Anhydrase from Pathogenic Bacterium <i>Vibrio cholerae</i>.

Demir-Yazıcı K., Güzel-Akdemir Ö., Angeli A., Supuran C., Akdemir A.

International journal of molecular sciences , vol.21, 2020 (SCI-Expanded, Scopus)

34. Development of Thiazolidinones as Fungal Carbonic Anhydrase Inhibitors.

Güzel-Akdemir Ö., Carradori S., Grande R., Demir-Yazıcı K., Angeli A., Supuran C., et al.

International journal of molecular sciences , vol.21, 2020 (SCI-Expanded, Scopus)

35. Evaluation of new 2-hydroxy-N-(4-oxo-2-substituted phenyl-1,3- thiazolidin-3-yl)-2-phenylacetamide derivatives as potential antimycobacterial agents

Guzel-Akdemir O., DEMİR YAZICI K., Trawally M., Dingis-Birgul S. İ., AKDEMİR A.

ORGANIC COMMUNICATIONS , vol.13, no.2, pp.33-50, 2020 (ESCI, Scopus, TRDizin)

36. rac- and meso-Cyclohexanoids: Their alpha-, beta-glycosidases, antibacterial, antifungal activities, and molecular docking studies

Karakilic E., Baran S., Ogutcu H., AKDEMİR A., Baran A.

ARCHIV DER PHARMAZIE , vol.353, 2020 (SCI-Expanded, Scopus)

37. Anticholinesterase and Antioxidant Activities of Natural Abietane Diterpenoids with Molecular Docking Studies

TOPÇU G., AKDEMİR A., Kolak U., Ozturk M., Boga M., BAHADORİ F., et al.

CURRENT ALZHEIMER RESEARCH , vol.17, no.3, pp.269-284, 2020 (SCI-Expanded, Scopus)

38. The Synthesis, Anticancer Activity, Structure-Activity Relationships and Molecular Modelling Studies of Novel Isoindole-1,3(2H)-dione Compounds Containing Different Functional Groups.

Tan A., Kizilkaya S., Kelestemur U., Akdemir A., Kara Y.

Anti-cancer agents in medicinal chemistry , vol.20, pp.1368-1378, 2020 (SCI-Expanded, Scopus) Sustainable Development

39. Synthesis and biological evaluation of new chloro/acetoxy substituted isoindole analogues as new tyrosine kinase inhibitors.

Köse A., Kaya M., Kishalı N., Akdemir A., Şahin E., Kara Y., et al.

Bioorganic chemistry , vol.94, pp.103421, 2020 (SCI-Expanded, Scopus)

40. Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies

ZENGİN KURT B., SÖNMEZ F., ÖZTÜRK D., AKDEMİR A., Angeli A., Supuran C. T.

European Journal Of Medicinal Chemistry , vol.183, pp.111702, 2019 (SCI-Expanded, Scopus)

41. Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold.

Rotondi G., Guglielmi P., Carradori S., Secci D., De Monte C., De Filippis B., et al.

Journal of enzyme inhibition and medicinal chemistry , vol.34, pp.1400-1413, 2019 (SCI-Expanded, Scopus)

42. Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies.

Ammazzalorso A., Carradorı S., Angelı A., Akdemir A., De Filippis B., Fantacuzzı M., et al.

Journal of enzyme inhibition and medicinal chemistry , vol.34, pp.1051-1061, 2019 (SCI-Expanded, Scopus)

43. Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme.

Akdemir A., ANGELI A., GÖKTAŞ F., Eraslan E., KARALı N., SUPURAN C.

Journal of enzyme inhibition and medicinal chemistry , vol.34, pp.528-531, 2019 (SCI-Expanded, Scopus)

44. Aromatase inhibition by 2-methyl indole hydrazone derivatives evaluated via molecular docking and in vitro activity studies.

OZCAN-SEZER S., INCE E., Akdemir A., CEYLAN Ö., Suzen S., GURER-ORHAN H.

Xenobiotica; the fate of foreign compounds in biological systems , vol.49, pp.549-556, 2019 (SCI-Expanded, Scopus)

45. Indole-Based Hydrazones Containing A Sulfonamide Moiety as Selective Inhibitors of Tumor-Associated Human Carbonic Anhydrase Isoforms IX and XII

Demir-Yazici K., BUA S., Akgunes N. M., Akdemir A., Supuran C. T., Guzel-Akdemir O.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , vol.20, no.9, 2019 (SCI-Expanded, Scopus)

46. Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors.

Güzel-Akdemır Ö., Angelı A., Demır K., Supuran C., Akdemir A.

Journal of enzyme inhibition and medicinal chemistry , vol.33, pp.1299-1308, 2018 (SCI-Expanded, Scopus)

47. A Study On Synthesis, Biological Activities and Molecular Modelling of Some Novel Trisubstituted 1,2,4-Triazole Derivatives

Gultekin E., KOLCUOĞLU Y., Akdemir A., Sirin Y., Bektas H., BEKİRCAN O.

CHEMISTRYSELECT , vol.3, no.31, pp.8813-8818, 2018 (SCI-Expanded, Scopus)

48. Five- and Six-Membered Nitrogen-Containing Compounds as Selective Carbonic Anhydrase Activators

Mollica A., Macedonio G., Stefanucci A., Carradori S., Akdemir A., ANGELI A., et al.

MOLECULES , vol.22, no.12, 2017 (SCI-Expanded, Scopus)

49. Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms.

D'ASCENZIO M., GUGLIELMI P., CARRADORI S., SECCI D., FLORIO R., MOLLICA A., et al.

Journal of enzyme inhibition and medicinal chemistry , vol.32, pp.51-59, 2017 (SCI-Expanded, Scopus) Sustainable Development

50. Synthesis and Functional Investigations of Computer Designed Novel Cladribine-Like Compounds for the Treatment of Multiple Sclerosis

Yavuz S., Cetin A., Akdemir A., Doyduk D., Disli A., Celik Turgut G., et al.

ARCHIV DER PHARMAZIE , vol.350, no.11, 2017 (SCI-Expanded, Scopus) Sustainable Development

51. Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases.

KARALı N., Akdemir A., GÖKTAŞ F., Eraslan E., ANGELI A., KıZıLıRMAK M., et al.

Bioorganic & medicinal chemistry , vol.25, pp.3714-3718, 2017 (SCI-Expanded, Scopus)

52. Computer design, synthesis, and bioactivity analyses of drugs like fingolimod used in the treatment of multiple sclerosis.

TURGUT G., DOYDUK D., YıLDıRıR Y., YAVUZ S., Akdemir A., DIŞLI A., et al.

Bioorganic & medicinal chemistry , vol.25, pp.483-495, 2017 (SCI-Expanded, Scopus)

53. Target Recognition Molecules and Molecular Modeling Studies

Çulhaoğlu B., Akdemir A.

Current Topics In Medicinal Chemistry , vol.17, no.13, pp.1580-1587, 2017 (SCI-Expanded, Scopus)

54. Isatin analogs as novel inhibitors of Candida spp. β-carbonic anhydrase enzymes.

Akdemir A., GÜZEL-AKDEMIR Ö., KARALı N., SUPURAN C.

Bioorganic & medicinal chemistry , vol.24, pp.1648-52, 2016 (SCI-Expanded, Scopus)

55. A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.

Carradorı S., Seccı D., De Monte C., Mollıca A., Ceruso M., Akdemir A., et al.

Bioorganic & medicinal chemistry , vol.24, pp.1095-105, 2016 (SCI-Expanded, Scopus)

56. A Divalent PAMAM-Based Matrix Metalloproteinase/Carbonic Anhydrase Inhibitor for the Treatment of Dry Eye Syndrome.

RICHICHI B., BALDONESCHI V., BURGALASSI S., FRAGAI M., VULLO D., Akdemir A., et al.

Chemistry (Weinheim an der Bergstrasse, Germany) , vol.22, pp.1714-21, 2016 (SCI-Expanded, Scopus)

57. Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives.

De Monte C., Carradorı S., Bızzarrı B., Bolasco A., Caprara F., Mollıca A., et al.

European journal of medicinal chemistry , vol.107, pp.82-96, 2016 (SCI-Expanded, Scopus)

58. Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies.

MOLLICA A., COSTANTE R., Akdemir A., CARRADORI S., STEFANUCCI A., MACEDONIO G., et al.

Bioorganic & medicinal chemistry , vol.23, pp.5311-8, 2015 (SCI-Expanded, Scopus)

59. New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: biological evaluation and molecular modelling studies.

Carradorı S., Mollıca A., Ceruso M., D'ascenzıo M., De Monte C., Chımentı P., et al.

Bioorganic & medicinal chemistry , vol.23, pp.2975-81, 2015 (SCI-Expanded, Scopus)

60. Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII.

GÜZEL-AKDEMIR Ö., Akdemir A., KARALı N., SUPURAN C.

Organic & biomolecular chemistry , vol.13, pp.6493-9, 2015 (SCI-Expanded, Scopus)

61. Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action.

Bozdag M., Carta F., Vullo D., Akdemir A., Isık S., Lanzı C., et al.

Bioorganic & medicinal chemistry , vol.23, pp.2368-76, 2015 (SCI-Expanded, Scopus)

62. Computational investigation of the selectivity of salen and tetrahydrosalen compounds towards the tumor-associated hCA XII isozyme.

Akdemir A., De Monte C., Carradorı S., Supuran C.

Journal of enzyme inhibition and medicinal chemistry , vol.30, pp.114-8, 2015 (SCI-Expanded, Scopus)

63. Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies.

D'ASCENZIO M., CARRADORI S., SECCI D., VULLO D., CERUSO M., Akdemir A., et al.

Bioorganic & medicinal chemistry , vol.22, pp.3982-8, 2014 (SCI-Expanded, Scopus)

64. Inhibition of tumor-associated human carbonic anhydrase isozymes IX and XII by a new class of substituted-phenylacetamido aromatic sulfonamides.

Akdemir A., GÜZEL-AKDEMIR Ö., SCOZZAFAVA A., CAPASSO C., SUPURAN C.

Bioorganic & medicinal chemistry , vol.21, pp.5228-32, 2013 (SCI-Expanded, Scopus)

65. A class of sulfonamides with strong inhibitory action against the α-carbonic anhydrase from Trypanosoma cruzi.

GÜZEL-AKDEMIR Ö., Akdemir A., PAN P., VERMELHO A., PARKKILA S., SCOZZAFAVA A., et al.

Journal of medicinal chemistry , vol.56, pp.5773-81, 2013 (SCI-Expanded, Scopus) Sustainable Development

66. Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo.

CARTA F., Akdemir A., SCOZZAFAVA A., MASINI E., SUPURAN C.

Journal of medicinal chemistry , vol.56, pp.4691-700, 2013 (SCI-Expanded, Scopus)

67. o-Benzenedisulfonimido-sulfonamides are potent inhibitors of the tumor-associated carbonic anhydrase isoforms CA IX and CA XII.

GÜZEL-AKDEMIR Ö., Akdemir A., ISIK S., VULLO D., SUPURAN C.

Bioorganic & medicinal chemistry , vol.21, pp.1386-91, 2013 (SCI-Expanded, Scopus)

68. The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.

Akdemir A., Vullo D., De Luca V., Scozzafava A., Cargınale V., Rossı M., et al.

Bioorganic & medicinal chemistry letters , vol.23, pp.1087-90, 2013 (SCI-Expanded, Scopus)

69. Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain.

Akdemir A., Edınk E., Thompson A., Lummıs S., Kooıstra A., De Graaf C., et al.

Bioorganic & medicinal chemistry , vol.20, pp.5992-6002, 2012 (SCI-Expanded, Scopus)

70. Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.

Edink E., Akdemir A., Jansen C., Van Elk R., Zuiderveld O., De Kanter F., et al.

Bioorganic & medicinal chemistry letters , vol.22, pp.1448-54, 2012 (SCI-Expanded, Scopus)

71. Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors.

Akdemir A., Rucktooa P., Jongejan A., Van Elk R., Bertrand S., Sixma T., et al.

Bioorganic & medicinal chemistry , vol.19, pp.6107-19, 2011 (SCI-Expanded, Scopus)

72. Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis.

Edınk E., Rucktooa P., Retra K., Akdemir A., Nahar T., Zuıderveld O., et al.

Journal of the American Chemical Society , vol.133, pp.5363-71, 2011 (SCI-Expanded, Scopus)

73. Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.

Ulens C., Akdemir A., Jongejan A., Van Elk R., Bertrand S., Perrakıs A., et al.

Journal of medicinal chemistry , vol.52, pp.2372-83, 2009 (SCI-Expanded, Scopus)

74. A G(q/11)-coupled mutant histamine H(1) receptor F435A activated solely by synthetic ligands (RASSL).

BRUYSTERS M., JONGEJAN A., Akdemir A., BAKKER R., LEURS R.

The Journal of biological chemistry , vol.280, pp.34741-6, 2005 (SCI-Expanded, Scopus)

Papers Presented at Peer-Reviewed Scientific Conferences 28

1. MANDELIC ACID-BASED NOVEL SPIROTHIAZOLIDINONES: SYNTHESIS, ANTIMYCOBACTERIAL ACTIVITY AND MOLECULAR MODELLING STUDIES

Trawally M., DEMİR YAZICI K., DİNGİŞ BİRGÜL S. İ., AKDEMİR A., GÜZEL AKDEMİR Ö.

13. International Symposium on Pharmaceutical Sciences (13. ISOPS), Ankara, Turkey, 22 June 2021, (Summary Text)

2. In Silico Design And Synthesis Of Novel 2-Acylhydrazono-5-Arylmethylene-4-Thiazolidinones As Enoyl-Acyl Carrier Protein Reductase Inhibitors

DİNGİŞ BİRGÜL S. İ., KÜÇÜKGÜZEL İ., AKDEMİR A.

13. International Symposium on Pharmaceutical Sciences (13. ISOPS), Ankara, Turkey, 22 June 2021, (Summary Text)

3. Computer aided design and synthesis of new ursane triterpenoids with nuclear factor kappa-B inhibition effect

Şenol H., Akdemir A., Topçu G.

7th International BAU Drug Design Congress, İstanbul, Turkey, 19 - 21 December 2019, pp.159-160, (Summary Text)

4. The application of molecular modelling studies to understand the selectivity and potency of several novel carbonic anhydrase inhibitors

Akdemir A.

the 4th International Satellite Meeting on Carbonic Anhydrase, Parma, Italy, 14 - 17 November 2019, (Unpublished)

5. Molecular docking and in vitro bioactivity of 5-fluoroindole derivatives on ER, aromatase and CYP1B1 activity in breast cancer cells

Ince E., Fatullayev H., AKDEMİR A., Suzen S., Gurer-Orhan H.

55th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology - Science Providing Solutions, Helsinki, Finland, 8 - 11 September 2019, vol.314, (Summary Text) Sustainable Development

6. Hit Identification Against DNA Topoisomerases Using Virtual Screenings

Akdemir A.

7. uluslararası ilaç kimyası kongresi, Antalya, Turkey, 14 - 17 March 2019, (Unpublished) Sustainable Development

7. Cytotoxic Effect of Novel 1-Ethyl and 2-Methyl Indole Derivatives on Breast Cancer Cells: ER and Aromatase as Their Potential Therapeutic Targets

İNCE E., TAŞCIOĞLU ALİYEV A., DURGUN K., AKDEMİR A., SÜZEN S., GÜRER ORHAN H.

6th International BAU Drug Design Congress, 13 - 15 December 2018, (Summary Text) Sustainable Development

8. Inhibition of Canavalia ensiformis urease with new 1,2,4-triazole compounds

KOLCUOĞLU Y., GÜLTEKİN E., BEKİRCAN O., AKDEMİR A.

1. EBAT CONGRESS, 27 - 30 October 2018, (Summary Text)

9. Evaluation of Anti-inflammatory Effect of Novel Fingolimod Based Compound F1-12h in SH-SY5Y, SK-N-SH and U-118MG Cells for the Efficancy in Multiple Sclerosis

ÇELİK TURGUT G., DOYDUK D., YILDIRIR Y., YAVUZ S., AKDEMİR A., DİŞLİ A., et al.

5th International Congress of the Molecular Biology Association of Turkey, 8 - 10 September 2018

10. Design and discovery of novel melatonin analogues as CYP1B1 inhibitors

İNCE E., KARAASLAN Ç., AKDEMİR A., SÜZEN S., GÜRER ORHAN H.

2nd international Gazi Pharma Synposium Series (GPSS-2017), 11 - 13 October 2017, (Summary Text)

11. Evaluation of Anti-inflammatory Effect of Novel Fingolimod Based Compound F1-12h in SH-SY5Y, SK-N-SH and U-118 MG Cells for the Efficacy in Multiple Sclerosis

ÇELİK TURGUT G., DOYDUK D., YILDIRIR Y., YAVUZ S., AKDEMİR A., DİŞLİ A., et al.

5th International Congress of the Molecular Biology Association of Turkey, 8 September - 10 December 2017, pp.31, (Summary Text)

12. Molecular modelling studies to guide sythesis programs of new thiourea compounds as putative inhibitors of hCA IX/XII and VcCA

GÜZEL AKDEMİR Ö., Demir K., KARALI N. L., AKDEMİR A.

3rd Satellite Meeting on Carbonic Anhydrase ’xx’xx New Trends in Carbonic Anhydrases Research’xx’xx, Montecatini Terme, ITALYA, Italy, 24 - 27 May 2017, (Summary Text)

13. Molecular modelling studies to guide synthesis programs of new thiourea compounds as putative inhibitors of hCA IX/XII and VcCA

Demir K., GÜZEL AKDEMİR Ö., KARALI N. L., AKDEMİR A.

3rd Satellite Meeting on Carbonic Anhydrase, 24 - 27 May 2017, pp.62, (Summary Text)

14. Structurally novel thiazolidinone-containing compounds that do not contain sulfonamide groups display antifungal activity

GÜZEL AKDEMİR Ö., CARREDORİ S., RİVANERA D., ÇAPAN G., AKDEMİR A.

3rd Satellite Meeting on Carbonic Anhydrase. New Trens in Carbonic Anhyrases Research, 24 - 27 May 2017, (Summary Text)

15. Eraslan Elma P., Akdemir A., Göktaş F., Karali N.L., Angeli A. , Kızılırmak M. , et al., ”Synthesis, biological evaluation and docking studies of structurally novel 1H-indole-2,3-dion 3-(N-phenylthiosemicarbazones) as potential hCA IX and XII inhibitors

ERASLAN P., AKDEMİR A., GÖKTAŞ F., KARALI N. L., Kızılırmak M., Supuran C. T.

3.İlaç ve Eczacılık Kongresi, İSTANBUL, TÜRKIYE, 26 - 29 April 2017, pp.871-872, (Summary Text)

16. Bazı Uvaol Türevlerinin Sentezi ve in vitro Biyokaitivitelerininİncelenmesi

ŞENOL H., TUNCAY S., GÜLER E. M., SEÇEN H., ÖCAL SUNGUROĞLU Z. N., AKDEMİR A., et al.

IVEK 3rd International Convention of Pharmaceuticals and Pharmacies3. Uluslararası İlaç ve Eczacılık Kongresi, İstanbul., 26 April - 29 January 2017, (Summary Text)

17. Nükleer Faktör Kappa-B İnhibisyon Etkili Ursan Türevi Triterpenlerin Sentezi

Şenol H., Tuncay S., Seçen H., Öcal N., Akdemir A., Topçu G.

Uluslararası Katılımlı 5. İlaç Kimyası: İlaç Etkin Maddesi Tasarımı, Sentezi, Üretimi ve Standardizasyonu Kongresi, Antalya, Turkey, 30 March - 02 April 2017, pp.131, (Full Text)

18. Nükleer Faktör Kappa-B İnhibisyon Etkili Ursan Türevi Triterpenlerin Sent

ŞENOL H., TUNCAY S., SEÇEN H., ÖCAL SUNGUROĞLU Z. N., AKDEMİR A., TOPÇU G.

Uluslararası Katılımlı5. İlaç Kimyası: İlaç Etkin Maddesi Tasarımı, Sentezi,Üretimi ve Standardizasyonu Kongresi, 30 March - 02 April 2017, (Summary Text)

19. In vitro and in silico evaluation of aromatase inhibitory activity of apigenin and amentoflavone; dual benefit of St. John's Wort in postmenopausal women

Tascioglu A., Ozcan S., AKDEMİR A., Gurer Orhan H.

EUROTOX 2016, Seville, Italy, 04 September 2016, (Full Text) Sustainable Development

20. Design, synthesis and investigation of dual benefits of 2-methyl indole derivatives in hormone-dependent breast cancer: Aromatase inhibitory and antioxidant activity

Ozcan Sezer S., İnci E., Öztürk Ceylan O., AKDEMİR A., Suzen S., Gurer Orhan H.

EUROTOX 2016, Seville, Italy, 04 September 2016, (Full Text) Sustainable Development

21. Structurally novel isatin derivatives as putative anticancer and antifungal agents

AKDEMİR A.

7th European Congress of Pharmacology (EPHAR2016), İstanbul, Turkey, 01 July 2016, pp.1, (Full Text)

22. Bilgisayar-destekli Antikolinesteraz 3-Hidroksiflavon Türevlerinin Sentezi ve in vitro Aktivite Çalışmaları.

BÜTÜN B., Akdemir A., TOPÇU G., Öztürk T.

2. Bilgisayar Destekli İlaç Tasarımı Kursu (Uygulamalı), İstanbul, Turkey, 16 May 2016, pp.163, (Full Text)

23. Molecular modelling studies to understand the effects of bioactive compounds on DNA and gene expression

AKDEMİR A.

TURKHELTOX Toxicology Congress, 9th Congress of the Turkish Society of Toxicology with participation of the Hellenic Society of Toxicology, İzmir, Turkey, 21 November 2015, pp.1, (Full Text)

24. The Search for Novel 3-hydroxyflavones with Anticholinergic Activity.

BÜTÜN B., Akdemir A., Öztürk T., TOPÇU G.

Royal Society of Chemistry, Medicinal Chemistry Residential School, Loughbrough, United Kingdom, 11 June 2015, pp.232, (Full Text)

25. Docking studies to investigate ligand-protein binding interactions in pharmaceutically important carbonic anhydrases

AKDEMİR A.

10th international carbonic anhydrase conference, Maastricht, Netherlands, 12 May 2015, pp.1, (Full Text)

26. Abietane diterpenoids as butyrylcholinesterase inhibitors from Salvia species

Topcu G., Akdemir A., Öztürk M. S., Boğa M., Kola U.

International Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF, New-York, United States Of America, 28 July - 01 August 2012, vol.78, pp.1229, (Summary Text)

27. Potent inhibitors of mitochondrial carbonic anhydrase isozymes CA-VA and CA-VB and brain-associated CA-VII

AKDEMİR A., Güzel Ö., Supuran C.

9th International conference on Carbonic Anhydrases (CA), İstanbul, Turkey, 11 April 2012, pp.1, (Full Text)

28. The quest for nicotinic receptor ligands by using AChBP as a template

AKDEMİR A., Jongejan A., Smit A., Smit T., Leurs R., de Esch I.

XIXst International Symposium on Medicinal Chemistry, İstanbul, Turkey, 29 August 2006, pp.25, (Full Text)

Books 4

4. Chapter 3. The acetylcholine binding protein as a template for the ligand binding domains of the homologous nicotinic receptors

AKDEMİR A., Leurs R., de Esch I. J.

in: Pharmacology of nicotinic acetylcholine receptors from the basic and therapeutic perspectives, Hugo R. Arias, Editor, Research Signpost, Kerala, pp.45-70, 2011

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